Thorne Ultimate-E contains all of the natural isomers of vitamin E and a higher level of Gamma-tocopherol. Tocopherols provide protection from free radicals and products of oxygenation, including lipid peroxides and singlet oxygen radicals. Gamma-tocopherol exhibits anti-inflammatory activity by inhibition of the enzyme cyclooxygenase, whereas alpha-tocopherol does not appear to have a significant effect on this enzyme.
Human studies comparing diets supplemented with both gamma- and alpha-tocopherols (more gamma than alpha) to diets supplemented primarily with alpha-tocopherol found more DNA protection in the mixed-tocopherol group than in the alpha-tocopherol only group. In in-vitro studies gamma-, but not alpha-, tocopherol inhibited nitric oxideinduced pancreatic beta-cell destruction, offering potential intervention in the pathogenesis of type 1 diabetes.
Oxidative stress is an important component of the atherosclerotic process, and thus antioxidants such as vitamin E are vital to the overall antioxidant capacity in the blood and tissues. Numerous clinical studies have shown vitamin E is beneficial to the cardiovascular system, and recent studies looking at mixed tocopherols have indicated they have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone, indicating a more potent antioxidant effect of mixed tocopherols. A number of clinical studies have shown vitamin E supplementation decreases the risk of cardiac events and increases longevity.
Supplementing with Ultimate-E, with its naturally occurring ratio of tocopherols, is an efficient way to supplement ALL of the naturally occurring vitamin E molecules, without the addition of soy oil as a filler. Thorne’s Ultimate-E contains pure, undiluted vitamin E. The vitamin E is extracted from a mixture of vegetable oils, including soy oil. However, any potentially allergenic soy residues are removed during the distillation process and, unlike most vitamin E products on the market, Ultimate-E is not diluted with soy oil! Because the tocopherols are from a natural source, the exact profile of tocopherols may vary slightly from batch to batch. Extra alpha-tocopherol is added to each batch to standardize the dose of this important tocopherol to 500 IU per capsule.
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