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PN THRN.SF721
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US$17.00 |
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| CO-10:
90 capsules. Like L-carnitine, coenzyme Q10 is absolutely necessary for proper myocardial function. CoQ10 is a vital component of energy production within the mitochondria of myocardial cells. CoQ10 is also an essential antioxidant that protects vascular endothelial cells from oxidative damage that can lead to decreased nitric oxide production, increased platelet aggregation, reduced blood flow, and an increased risk of atherosclerosis and coronary events. Type II diabetics, who commonly exhibit poor endothelial function and an increased risk of cardiovascular disease, were given 200 mg CoQ10 daily and demonstrated significantly improved endothelial function. |
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PN THRN.SF751
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US$32.85 |
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| Choleast:
120 capsules. After a check of their cholesterol levels and the subsequent prescription for a lipid-lowering “statin” drug, many patients express concern over potential adverse effects of drug therapy. Choleast is a natural alternative to the prescription drugs most often used in this case. Choleast is a
lipid-lowering supplement containing red yeast rice, Monascus purpureus, a red-pigmented yeast grown on rice. Red yeast rice has been found to significantly benefit blood lipid levels, including total cholesterol, LDL cholesterol, and triglycerides. Numerous scientific studies in China and the United States have proven red yeast rice preparations to be helpful in establishing normal blood lipid levels. This is important, as maintaining optimal cholesterol and triglyceride levels has been shown to reduce the incidence of myocardial infarction. Red yeast rice appears to exert its influence on blood lipids by inhibiting the enzyme HMG-CoA reductase; the lipid-lowering “statin” drugs inhibit this enzyme as well. In contrast to drugs that contain one isolated synthetic HMG-CoA-reductase-inhibiting molecule, red yeast rice contains nine naturally-occurring HMG-CoA reductase-inhibitor compounds, phytosterols (beta-sitosterol, campesterol, and stigmasterol), isoflavones, and trace minerals. There is scientific evidence that inhibition of HMG-CoA reductase, in addition to inhibiting cholesterol biosynthesis, can also inhibit production of Coenzyme Q10 (CoQ10), the ubiquitous antioxidant and energy-producing nutrient vital to mitochondrial function. While it remains to be researched whether red yeast rice can cause this same deficiency in humans, one animal study suggests this is a possibility. To safeguard against CoQ10 depletion, Choleast contains 15 mg CoQ10 per capsule. |
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PN THRN.SF786
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US$13.70 |
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| Thiocid:
60 capsules. Alpha-lipoic acid (ALA) exerts its potent antioxidant effects in both its oxidized and reduced forms. It helps recycle other antioxidants, including glutathione – an essential antioxidant for liver detoxification. Alpha-lipoic acid has historically provided benefit after toxic insults to the liver. For example, lipoic acid infusions were used in the treatment of amanita mushroom poisoning in 75 patients between 1974 and 1978. Normally, up to 50 percent of patients recover without intervention; however, 89 percent (67 of 75) recovered after lipoic acid infusion. ALA appears to improve tissue redox status in metal toxicity and during chelation with dithiol compounds, including dimercaptosuccinic acid (DMSA). In addition to its antioxidant effects, alpha-lipoic acid (ALA) appears capable of chelating certain metals. In animal studies, it has been found to protect against arsenic poisoning and cadmium-induced hepatotoxicity. In vitro, ALA chelated mercury from renal slices. While in vitro and animal studies indicate superior bioavailability of pure R-lipoic acid, many clinical studies have used the racemic mixture. Thorne offers customers a choice by providing two dosage options of alpha-lipoic acid, containing the racemic mixture of R and S. Thiocid provides 100 mg
alpha-lipoic acid per capsule, providing an effective dose for prevention or pediatric use. |
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PN THRN.SF787
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US$34.80 |
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| Methyl-Guard:
180 capsules. Elevated plasma homocysteine has joined cholesterol and triglycerides as a leading indicator of risk for cardiovascular disease. In addition to increased risk for cardiovascular disease, high plasma homocysteine levels have been epidemiologically and clinically implicated in osteoporosis, recurrent miscarriage, cognitive decline, and other neuropsychiatric disorders. Numerous studies advocate lowering plasma homocysteine levels via nutritional supplementation. A number of biochemical abnormalities can raise homocysteine levels. These biochemical defects can be addressed by providing proper nutrient cofactors. Folic acid (as 5-methyl-tetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine) are involved in recycling homocysteine to the amino acid methionine, while the breakdown of homocysteine into the beneficial amino acids cysteine and taurine is facilitated by pyridoxal 5’-phosphate (the active form of vitamin B6). Clinical studies have shown each of these nutrients can help lower plasma homocysteine levels. In addition to the homocysteine-reducing effects of the ingredients in Methyl-Guard, folic acid has been shown to improve vascular endothelial function, working as a cofactor with vitamin C for L-arginine-induced nitric oxide production. Homocysteine is increased in individuals with a common genetic defect involving the enzyme responsible for conversion of folic acid to the active methyl donor 5-methyl-tetrahydrofolate (5-MTHF). Because of this, Methyl-Guard contains 400 mcg of active 5-MTHF per capsule. Elevated homocysteine is a known risk factor for cognitive impairment and Alzheimer’s disease. Significant deficiencies in homocysteine-metabolizing cofactors are commonly seen in the elderly population, with a resultant increase in homocysteine with advancing age. Vascular damage can be caused by elevated homocysteine, resulting in an increased risk of multiple brain infarcts and dementia. Elevated homocysteine levels associated with aging, as well as low levels of folic acid and vitamins B6 and B12, can result in hypomethylation of numerous substances, including DNA and proteins. This in turn renders vascular structures and neurons more susceptible to damage and cell death. Providing the nutritional cofactors for proper functioning of the methionine cycle may improve methylation and protect the brain from damage. Methyl-Guard was the first homocysteine-lowering supplement on the market, and is the only one that contains the active, body-ready forms of all the homocysteine-metabolizing nutrient cofactors. |
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PN THRN.SP617
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US$52.00 |
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| CoQ100:
90 gelcaps. Present in the mitochondria of every cell, coenzyme Q10 is an essential factor in ATP production. The need for CoQ10 appears to be greatest in metabolically-active cells such as in the heart, gingiva, immune system, and gastric mucosa. CoQ10 is also an antioxidant, and appears to recycle vitamin E. |
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PN THRN.SP651
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US$41.50 |
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| Pharmacol-40:
90 capsules. In an effort to reduce cardiovascular disease risk, many health-care practitioners suggest dietary changes and prescribe substances to improve blood lipid levels. Some of the methods employed, such as HMG CoA reductase-inhibiting (statin) drugs, are not well-tolerated by some patients,
while other individuals are opposed to taking these drugs. In addition, some individuals do not reach target serum cholesterol and LDL levels with statin drugs alone. Most of the cholesterol in the bloodstream is produced in the liver, with a smaller amount derived from the diet. Addressing both hepatic production and gastrointestinal absorption of cholesterol can be of benefit in maintaining normal cholesterol levels. Pharmacol-40 is a specific low-molecular weight polysaccharide derived from the enzymatic hydrolysis of chitin, a polyglucosamine substance found in crab and shrimp shells. Pharmacol-40 is a large molecule that resists digestion and therefore is not absorbed into the bloodstream – instead, it remains in the gastrointestinal tract where it attaches to dietary cholesterol, forming an insoluble complex that is not absorbed. Pharmacol-40 also binds cholesterol produced in the liver and secreted in the bile, preventing its reabsorption in the intestines. In a placebo-controlled, multicenter, clinical trial, 105 patients with mild-to-moderate hypercholesterolemia were randomized to receive HEP-40 (the active ingredient in Pharmacol-40) at varying doses or placebo and were evaluated at baseline, four, eight, and 12 weeks. A significant decrease in LDL cholesterol was observed, compared to placebo, in the group taking 2,400 mg once daily (-16.9%; p=0.002). Since Pharmacol-40 binds to cholesterol in the gut, the researchers assessed whether fat-soluble vitamin absorption might be inhibited. Serum 25(OH) vitamin D levels were tested in a random sample of 91 patients and 22 in the placebo group at baseline and at 12 weeks. No significant difference was seen between groups. This study showed Pharmacol-40 is efficacious in reducing serum LDL cholesterol and is safe and well tolerated. Pharmacol-40 has shown significant benefit by itself, and can be used in conjunction with Choleast and Super EPA for maximum maintenance of lipid levels. |
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PN THRN.SA511
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US$10.60 |
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| Taurine:
90 capsules. Taurine is a conditionally essential, sulfur-containing amino acid that is found in the tissues of most animal species. It is not incorporated into proteins, but is found free in many tissues. Taurine is involved in a number of physiological processes including bile acid conjugation, osmoregulation,
detoxification of xenobiotics, cell membrane stabilization, modulation of cellular calcium flux, and regulation of neuronal excitability. Conjugation of bile acids by taurine results in increased cholesterol solubility and excretion. Low levels of taurine have been associated with retinal degeneration, growth retardation, and cardiomyopathy. Individuals who are taurine deficient may be more susceptible to tissue damage by xenobiotics including aldehydes, chlorine, and amines. Taurine has been used clinically in the treatment of cardiovascular diseases, hypercholesterolemia, seizure disorders, ocular disorders, diabetes, Alzheimer’s disease, hepatic disease, cystic fibrosis, and alcoholism. Taurine is the most abundant amino acid in the heart. Taken supplementally, taurine helps stabilize heart rhythm, improves cardiac function and blood lipid levels, and may help normalize blood pressure. In a seven-week study of obese, non-diabetic patients, taurine (3 grams daily) significantly improved serum triglycerides, total cholesterol, HDL cholesterol, and body weight. Taurine has also been shown to improve nitric oxide production in the vascular endothelium, which is essential to blood flow, blood pressure regulation, and overall cardiovascular functioning. This improvement in vascular endothelial function is significant, as endothelial dysfunction is one of the earliest events in the formation of atherosclerotic lesions. Taurine acts as an antioxidant as well, inhibiting LDL cholesterol oxidation. Taurine significantly improved cardiac function in patients with congestive heart failure. In one study, in which patients were given 3 grams daily for six weeks, taurine dosing significantly improved left ventricular function. Other clinical studies echo these results, showing significant improvement in congestive heart failure. |
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PN THRN.SA520
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US$50.70 |
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| Carnityl:
60 capsules. Acetyl-L-carnitine (ALC) is an ester of the trimethylated amino acid, L-carnitine, and is synthesized from L-carnitine in the brain, liver, and kidney. Acetyl-L-carnitine facilitates the uptake of acetyl CoA into the mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and cell membrane phospholipid synthesis. Taken supplementally, ALC is better absorbed and crosses the blood-brain barrier better than L-carnitine. Several studies have demonstrated ALC’s effectiveness in Alzheimer’s disease, especially if supplementation is begun early in the disease process. Other studies have shown ALC may be of benefit for depression in the elderly, possibly by partially inhibiting the activity of the hypothalamic-pituitary-adrenal axis and lowering chronically elevated cortisol levels. ALC has also demonstrated benefit in diabetic, HIV-associated, and chemotherapy-induced neuropathies, ischemia and reperfusion of the brain, and cognitive impairment of alcoholics. Therapeutic doses of acetyl-L-carnitine range from 1,500 to 3,000 mg daily, in divided doses. |
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PN THRN.SA525
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US$32.95 |
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| Perfusia-SR:
180 capsules. Perfusia-SR is a sustained-release formulation of the amino acid L-arginine. Supplementation with L-arginine improves the production of nitric oxide by vascular endothelial cells, which increases vasodilation while inhibiting platelet and monocyte adhesiveness, resulting, for example, in enhanced cardiovascular health and erectile function. This unique, sustained-release product provides for improved long-term blood levels with twice daily dosing. |
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PN THRN.SF713
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US$29.25 |
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| Q10 Plus:
90 capsules. This combination of coenzyme Q10, hawthorne (Crataegus oxycantha), potassium, taurine, and magnesium provides the heart muscle with the nutrients needed for optimal functioning. CoQ10 is a vital element for the heart. Myocardial cells are highly metabolic and thus need CoQ10 as a mitochondrial energy-producing cofactor. CoQ10 also serves as an intracellular antioxidant. Studies on CoQ10 in cardiovascular function show its benefit in patients with angina, arrhythmia, mitral valve prolapse, hypertension, and congestive heart failure. In 73 patients after an acute myocardial infarction treated with 120 mg/day, significant improvements were seen in angina, arrhythmia, and poor left ventricular function (all p<0.005 compared to placebo) after 28 days’ treatment. Cardiac events and death were also significantly reduced in the CoQ10 group. Taurine is an essential nutrient cofactor for cardiac function, and is the most abundant amino acid in the heart. Research indicates supplementation with taurine results in reduced serum cholesterol levels, probably due to taurine’s contribution to the formation of bile acids. In addition, taurine aids in the regulation of intracellular calcium levels, which protects the heart muscle and helps regulate cardiac rhythmicity. Taurine may also have hypotensive activity. Flavonoid compounds in hawthorne appear to strengthen blood vessels and stabilize heart rhythm, whereas, flavonoids in Ginkgo enhance blood flow. Hawthorne has been shown to improve cardiac function in individuals with congestive heart failure, with improvements in blood pressure, heart rate, dyspnea, and exercise capacity. The flavonoids in hawthorne and Ginkgo act as antioxidants and may improve vascular endothelial function, which can result in increased vascular dilation and blood flow. Magnesium and potassium are necessary for proper cardiovascular function. This combination of nutrients and botanicals relaxes blood vessels, leading to optimization of blood pressure. Magnesium has demonstrated improvement in mitral valve prolapse symptoms, hyperlipidemia, and
hypertension. Potassium supplementation has benefited individuals with hypertension. Potassium and magnesium supplementation may also be of benefit in congestive heart failure. |
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