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PN THRN.SF780
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US$17.30 |
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| Melaton-5:
60 capsules. Various cancer types have been shown to be responsive to oral melatonin (10-50 mg daily), including breast cancer, non-small-cell lung cancer, metastatic renal-cell carcinoma, hepatocellular carcinoma, and brain metastases from solid tumors. In a study of 30 patients with untreatable metastatic solid tumors, 20 mg oral melatonin daily in conjunction with low doses of the antitumor cytokines, interleukin-2 and -12, significantly increased lymphocyte proliferation and the anticancer effect of these cytokines. Research observing the use of melatonin alone or in conjunction with chemotherapy found melatonin may be a beneficial therapeutic tool for patients with colorectal cancer, soft tissue sarcoma, or metastatic hepatocellular carcinoma. A meta-analysis of 10 randomized, controlled trials demonstrated melatonin therapy for various cancers reduced the relative risk of death at one year by an average of 34 percent. These results were independent of cancer type and melatonin dosage, which ranged from 10-40 mg daily; no adverse events were reported. In a study of 14 metastatic breast cancer patients who had not responded to initial therapy with tamoxifen, 20 mg of melatonin was administered daily in the evening along with tamoxifen. A partial response was seen in 28 percent of patients whose disease would have otherwise been expected to progress rapidly. In those who responded clinically, significant declines were also found in serum levels of the tumor growth factor IGF-1. This response was irrespective of estrogen-receptor status. Thorne’s Melaton-5 supplies 5 mg of melatonin in each capsule, to accommodate a higher dosage regimen. Timing of the melatonin dosage appears to be important, with the most effective protocol being a diurnal cycle similar to the physiological rhythm of melatonin secretion (once daily dosing in the evening before bed). |
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PN THRN.SF781
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US$9.30 |
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| Melaton-1:
90 capsules. Melatonin administration, regardless of dosage time, exerts a hypnotic and sedative effect when given in doses of 0.3-5.0 mg. If taken before onset of endogenous melatonin secretion, even low doses can induce sleep. Melatonin is thought to potentiate the affects of gamma-aminobutyric acid (GABA) via direct interaction with GABA receptors. Research indicates melatonin exerts a sleep-promoting action by accelerating sleep initiation, improving sleep maintenance, and marginally altering sleep architecture. Thorne’s Melaton-1 supplies 1 mg of melatonin in each capsule. This potency is ideal for those patients who may only require a low dose of melatonin to help with sleep or maintaining normal circadian rhythm. |
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PN THRN.SP652
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US$21.90 |
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| PharmaGABA-Pro:
60 capsules. Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, insomnia, seizures, and movement disorders, it must be balanced with inhibition. GABA – the most important inhibitory neurotransmitter in the brain – provides this inhibition, acting like a “brake” during times of runaway stress. Medications for anxiety, such as benzodiazepines, stimulate GABA receptors and induce relaxation. Either low GABA levels or decreased GABA function in the brain is associated with several psychiatric and neurological disorders, including anxiety, depression, insomnia, and epilepsy. Studies indicate GABA can improve relaxation and enhance sleep. The natural GABA in PharmaGABA-PRO is produced via a fermentation process that utilizes Lactobacillus hilgardii – the bacteria used to ferment vegetables in the preparation of the traditional Korean dish known as kimchi. Clinical studies have shown that natural PharmaGABA increases the production of brain alpha-waves, creating a profound sense of physical relaxation while maintaining mental focus. In contrast, stressrelated beta-waves are decreased. In addition to changes in brain waves, PharmaGABA has been shown to produce relaxation as evidenced by reduced pupil diameter, heart rate, and markers of stress – salivary cortisol and chromogranin A. In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, synthetic GABA did not demonstrate these effects. |
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PN BGEN.290
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US$40.00 |
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| Sleep Factors:
60 capsules. A comprehensive, non-habit forming formula of amino acids, botanicals, and melatonin that promotes a healthy and soothing night of sleep. Promotes healthy circadian rhythms. Provides nutritional neuro-endocrine support for normal sleep patterns. A safe and well tolerated combination of nervine and sedative botanicals. Essential minerals for muscle relaxation. Neuro-endocrine Nutrient Support: Melatonin is the principle hormone responsible for healthy circadian rhythms and normal sleep cycles. It is produced from L-tryptophan, which is converted to 5-HTP, then to serotonin, and finally to melatonin. Both L-tryptophan and 5-HTP can cross the blood brain barrier and increase the endogenous production of serotonin and melatonin, and have been shown to have their own sedating effects. Melatonin and L-theanine also increase GABA, the primary inhibitory neurotransmitter in the CNS which exerts an overall calming effect on the body. Inositol is another nutrient that may also have a relaxing effect. It is thought to positively affect serotonin receptors and promote a beneficial emotional response. These nutrients work together synergistically to modulate the hormones and neurotransmitters responsible for restorative and regenerative sleep. Melatonin: regulated by the normal light and dark cycles of night and day. Darkness stimulates the secretion of melatonin while light exposure causes its endogenous breakdown and inhibits production. When exposed to prolonged times of darkness endogenous production of melatonin will decrease. Low levels of melatonin are found in those who have difficulty falling asleep and staying asleep, the elderly, and people with conditions associated with decreased serotonin levels including chronic pain conditions and mood disturbances. Melatonin may effectively facilitate the discontinuation of benzodiazepine therapy and help improve sleep quality in those experiencing jet lag. Tryptophan: has been shown to have a significant sedative-like effect but does not impair performance like sedative medications. Tryptophan deficiency causes a reduction in serotonin production in the CNS causing mood disturbances, memory impairment, aggression, and sleep disturbance. 5-HTP (5-Hydroxytryptophan): the biochemical intermediate in the conversion of L-tryptophan to serotonin. 5-HTP readily crosses the blood-brain barrier and increases central nervous system (CNS) synthesis of serotonin. Serotonin can affect sleep, appetite, temperature, sexual behavior, and pain sensation. 5-HTP’s beneficial effect on serotonin and melatonin may be why it has been shown to improve REM sleep. Calming Botanicals: Valerian (Valeriana officinalis) is a popular herb used as a natural sleep aid to support restful sleep. Its popularity is due to the fact that most people do not experience the morning sleepiness that is common with benzodiazepine medications. Traditionally, calming and sedative herbs have been combined to potentiate the therapeutic effect of the formula. In BioGenesis’s Sleep Factors higher dose nervine herbs such as Scutellaria lateriflora, Passiflora incarnata, Lactuca virosa, Matricaria chamomilla, and Humulus lupulus are combined with lower dose sedating herbs including Piscidia piscipula, Zizyphus jujube, and Eschscholzia California. Relaxing Minerals: Calcium and magnesium are essential minerals in the body responsible for hundreds of reactions in the body. When taken together they improve muscle contraction and relaxation, cellular energy production, and nerve cell conduction. These essential minerals can have spasmolytic effects on tight, tense muscles promoting an undisturbed and comfortable slumber. |
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PN VNTR.VNME10
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US$23.90 |
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| Melatonin:
10 mg. MELATONIN is a hormone secreted by the pineal gland, an endocrine gland buried deep in the brain that regulates sleep. It is responsible for regulating biological rhythms in humans. Melatonin is a powerful antioxidant and free radical scavenger. There is evidence that melatonin acts to support the immune system. As we age the natural production of melatonin tapers off. |
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PN VNTR.VNVR
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US$16.30 |
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| Valerian Extract:
60 capsules, 250 mg. VALERIAN EXTRACT can be used as a relaxant, a nerve tonic, and may help relax smooth muscles. |
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PN VTAN.01045-3
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US$18.50 |
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| SleepBlend:
60 capsules. SleepBlend is a well-rounded product that was developed to improve all aspects of sleep - falling asleep, frequent waking, awaking prematurely. Utilizing scientific research, clinical experience and traditional herbal medicine it promotes balanced biorhythms in a non-addictive, safe and effective formula. Each vegetarian suitable capsule includes: Riboflavin (Vitamin B2, riboflavin-5-phosphate), Vitamin B6 (as pyridoxine), Vitamin B12 (as methylcobalamin), Calcium (as citrate-malate), Magnesium (as citrate-malate), Passionflower extract (.4% total flavanoids), Hops flower, Valerian root extract (0.8% valerenic acid), 5-Hydroxy tryptophan, Melatonin |
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PN VTAN.01046-0
Ships within 8 days |
US$5.00 |
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| SleepBlend:
15 capsules. SleepBlend is a well-rounded product that was developed to improve all aspects of sleep - falling asleep, frequent waking, awaking prematurely. Utilizing scientific research, clinical experience and traditional herbal medicine it promotes balanced biorhythms in a non-addictive, safe and effective formula. Each vegetarian suitable capsule includes: Riboflavin (Vitamin B2, riboflavin-5-phosphate), Vitamin B6 (as pyridoxine), Vitamin B12 (as methylcobalamin), Calcium (as citrate-malate), Magnesium (as citrate-malate), Passionflower extract (.4% total flavanoids), Hops flower, Valerian root extract (0.8% valerenic acid), 5-Hydroxy tryptophan, Melatonin |
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PN ITIX.266004
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US$20.60 |
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| PSI Nighttime:
60 ultracaps. Why use supplements for muscle support? Because the right ingredients work with the body's own anti-inflammatory response, and help keep muscle and connective tissue functioning properly. Why take PSI Nighttime? It supports the body's own anti-inflammatory response and natural relaxation for healthy sleep. Used clinically for over 15 years, PSI Nighttime is an effective relaxation formula that supports normal musculoskeletal function range of motion following occasional overuse. PSI Daytime also available. While willow bark naturally contains salicylic acid, which works with the body's own anti-inflammatory response. Bromelain is an enzyme sourced from pineapple that can be used for muscle support following occasional overexertion or overuse. Valerian and hops support relaxation and deep, restful sleep to help the body's own natural recovery and anti-inflammatory process. |
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PN ITIX.73233
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US$14.50 |
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| End Fatigue Revitalizing Sleep Formula:
30 ultracaps. Why be concerned about sleep quality? Daytime alertness and daily rejuvenation depends on it. Quality nighttime sleep is crucial for daytime energy, and gives your mind and body a chance to relax and rebuild. Why End Fatigue™ Revitalizing Sleep Formula? You fall asleep fast. The ingredients help you fall asleep faster and maintain a healthy sleep cycle - without feeling groggy the next day. You stay asleep. Improves the quality of restful sleep so you wake up energized and relaxed. You make the most of your sleep. The Revitalizing Sleep Formula helps your body - especially your muscles - recuperate while you sleep so you experience less fatigue. |
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